This work was supported by the Way-Klingler College of Arts and Sciences 2011 Way-Klingler Teaching Enhancement Award granted to T.J.E., M.M., and M.St.M. We acknowledge the support of A. Riley and L. MacBride, Institutional Research at Marquette University, in data access, handling, and analysis. We thank Lisa Petrella, Marquette University, and Shannon Colton and Gina Vogt, program directors of the Center for Biomolecular Modeling at the Milwaukee School of Engineering, for categorizing the assessment questions. The authors also acknowledge the teaching and publishing community for many interactive discussions on teaching at a variety of workshops, with a particular mention of the National Academies Summer Institute on Undergraduate Education in Biology (www.academiessummerinstitute.org), which T.J.E. and M.M. attended in 2006.