The ongoing efforts in introductory biology are part of a larger transformation at ISU supported by a Howard Hughes Medical Institute (HHMI) Engage to Excel grant. The transformation of introductory biology is a result of the efforts of 10 instructors, science-teaching postdoctoral fellows, graduate teaching assistants, and undergraduate learning assistants at ISU. We thank Thomas Holme, Kimberly Linenberger, and Cynthia Luxford and instructors Philip Becraft, Jeffrey Essner, Stephen H. Howell, Sayali Kukday, Thomas Peterson, Donald S. Sakaguchi, David Vleck, and Yanhai Yin for their invaluable help in designing and implementing this project. The protocol for using students as human subjects was approved by ISU Institutional Review Board, 12–392. E.J.G. was supported in part by a fellowship from the ISU Office of Biotechnology.